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doi: 10.1523/JNEUROSCI.23-33-10622.2003

A safety investigation of prevalent anti-osteoporotic medications in patients with type 2 diabetes mellitus and osteoporosis revealed that bisphosphonates (BPs) enhanced bone mineral density and diminished fracture risk irrespective of diabetes status, although did not ameliorate the diabetic condition (Eastell et al., 2020)

Nonetheless, it provides relevant context

The muscle-loss data especially deserves more attention when counseling patients

Only 1 in 100 people with lighter skin tones have melanonychia, but 70 in 100 with darker skin tones have it

For individuals taking glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity), or the dual GIP/GLP-1 receptor agonist tirzepatide (Mounjaro, Zepbound), maintaining adequate magnesium status may be particularly important