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Risk factors for accelerated B12 depletion include prior gastric surgery, pernicious anemia history, metformin use, veganism or vegetarian diet, and genetic variants in B12 metabolism

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What studies like this keep exposing is how interconnected these systems are in lived experience

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Melatonin works by binding to specific receptors in the brain (MT1 and MT2 receptors) that help promote sleepiness and regulate the body's internal clock