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Using a cecal ligation and puncture (CLP) murine model, in vitro microglia-neuron co-cultures, data-independent acquisition (DIA) proteomics and liquid chromatography-mass spectrometry (LC-MS) metabolomics, SAE neuropathology and phenotypes were characterized

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Key metrics to track: Time to fall asleep (sleep latency) Number of nighttime awakenings Deep sleep percentage (if using a wearable) Morning alertness and energy Daytime cognitive performance Stress and cortisol management DSIP's effects on the HPA axis and cortisol regulation suggest potential benefits for stress-related sleep problems

Cell 166 , 6376 (2016)

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If GI symptoms do not improve after eight weeks at a stable dose, that is a signal to discuss dose reduction or discontinuation with your prescribing doctor