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Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only

20% in the placebo group (risk ratio 2.25

4.2.1 Stability in Aqueous Solutions In aqueous solution at 25C, SAG exhibits significantly greater stability than unmodified GSH, with substantially lower oxidation rates under identical conditions

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Meanwhile, it may take months to years to see long-term effects

As can be seen from Figure 9A, the highly conserved residues Cys 290 and Glu 256 are located in a suitable spatial arrangement to the carbonyl of the MSA substrate