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Scortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H et al

Persistent nausea that interferes with hydration, nutrition, or daily function should be discussed with a healthcare professional rather than assumed to be a normal adjustment symptom

The distinct contributions of each receptor system - GLP-1-mediated improvements in insulin sensitivity and appetite regulation, GIP-mediated enhancement of insulin secretion and adipose tissue function, and glucagon-mediated direct hepatic metabolic modulation and increased energy expenditure - create synergistic benefits when engaged through dual or triple agonist formulations

Note that a dipeptidyl peptidase 4 (DPP-4) inhibitor can be discontinued when adding GLP-1RA because they are both incretin-based therapies and the DPP-4 inhibitor is redundant in that situation

Collectively, these findings highlight that patients with PCOS frequently meet traditional criteria for GLP-1 RA therapy and show gradual increase among GLP-1 RA users

Curr Ther Res Clin Exp 63: 621-633