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Clin Pharmacol Ther 51(5):522526 Cribb AE, Spielberg SP, Griffin GP (1995) N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes

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Researchers noted that the SASP factors secreted by senescent PDAC cells included pro-angiogenic agents that contributed to increased tumor vascularization [39]