Essential B vitamins, including folic acid and vitamin B12, play a crucial role in energy metabolism, helping to convert food into usable energy and supporting overall vitality
The sensation of feeling cold appears to be an indirect consequence of the metabolic and body composition changes induced by the medication, rather than a direct drug effect on temperature regulation centres in the hypothalamus
These medications include semaglutide (Ozempic, Wegovy, Rybelsus), tirzepatide (Mounjaro, Zepbound)which is actually a dual GIP/GLP-1 receptor agonistdulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)
( Excellent discussion of the challenges of conducting clinical trials in obesity ) Pi-Sunyer X, Astrup A, Fujioka K, Greenway F, Halpern A, Krempf M, Lau DC, le Roux CW, Violante Ortiz R, Jensen CB, Wilding JP, SCALE Obesity and Prediabetes NN8022-1839 Study Group
And Ian, in his book, talks about that we share a common ancestor
560 Presenilin mutations in patients with AD may contribute to neurodegeneration by downregulating GPX4 and promoting ferroptosis