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As a natural low-molecular antioxidant and electron donor, glutathione is involved in maintaining cellular homeostasis and plays a key role in protecting cells from oxidative stress, inhibiting apoptosis, and is also necessary for the detoxification of xenobiotics, drug metabolism, etc

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The MetaCyc database of metabolic pathways and enzymes - a 2019 update

However, for some individuals with residual absorption capabilities, high-dose oral supplements can serve as an alternative

Each of these is a lever you can use to compress or extend the timeline

Coron Artery Dis 2020, 31(3): 306-314