With the majority of expenditure related to long-term complications, the relative effectiveness and long-term cost-effectiveness profiles of antidiabetic agents is particularly pertinent for the UK setting to help manage overall healthcare expenditure while delivering the best outcomes for patients [9]
By activating GIP receptors, tirzepatide enhances insulin secretion in a glucose-dependent manner, meaning it stimulates insulin release only when blood glucose levels are elevated
Injection site rotation Rotate injection sites with each weekly dose

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Higher maintenance doses (such as 2.4 mg weekly for weight management) are associated with more persistent gastrointestinal symptoms compared to lower doses used for diabetes management
Glycemic targets: standards of medical care in diabetes-2018