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It is derived from a fragment of adrenocorticotropic hormone (ACTH) with an added Pro-Gly-Pro tail for stability, and is most commonly studied as an intranasal nootropic and neuroprotective peptide

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Semax modulates expression of genes linked to neurotrophins, cytokines, neurotransmission, and vascular remodeling, with robust upregulation of brain-derived neurotrophic factor (BDNF) and related neuroprotective transcripts in animal models

On the thyroid forum they usually suggest private testing of all the thyroid hormones