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Fluctuations in NRF2 levels predict the chemotherapy response and survival outcomes of NSCLC patients receiving neoadjuvant chemotherapy, and unaltered NRF2 expression correlates with poor survival rates and chemotherapy resistance in NSCLC patients [98]

Key Results from Clinical Trials: Significant Weight Loss: Patients achieved weight loss ranging from 15% to 24%, depending on dosage and treatment duration.This makes Retatrutide one of the most effective weight-loss drugs in clinical trials to date

However, when emodin, rhein and to a lesser extent cis -stilbene, were used in combination with each topoisomerase II inhibitor, there was an antagonistic increase in ATP, an inhibition of apoptosis and no cell-cycle arrest