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The required dose is 20 to 40 mg (milligram) per kg body weight of 1 g (gram) to 2 g per day in two divided doses

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not therapeutic claims

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The 13 amino acid N-terminal extension further adds to the peptides shelf life and resistance to breakdown, and this 13-amino acid extension results in a dramatically extended half-life of about 20-30 hours compared to the mere minutes of native IGF-1

This low-grade systemic inflammation: Impairs insulin receptor signalling, directly worsening insulin resistance Damages ovarian granulosa cells, impairing egg development and ovarian function Disrupts gut barrier integrity, contributing to what some researchers call a "leaky gut" pattern associated with systemic inflammation Amplifies HPA axis dysregulation, raising cortisol and further disrupting sex hormone balance Chronic inflammation is both a consequence of PMOS and a driver that perpetuates it