Progressive worsening over weeks
This is a 52-week, randomized, double-blind, double-dummy, active- and placebo-controlled, parallel-group, multicentred trial conducted at 100 trial sites in 12 countries
A competent prescriber understands obesity as a disease, the full medication toolkit, the controlled-substance compliance phentermine requires, the side-effect and lean-mass considerations semaglutide brings, and the program-level judgment that decides when to use one, the other, or both in sequence
It is meant to be used in conjunction with a reduced-calorie diet and increased physical activity
The study, published Thursday in the Journal of the American Medical Association (JAMA), excluded patients with diabetes
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