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Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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Notably, exposure to Met had no effect on sulfate assimilation in scon deletion mutants, while in wild-type, Met exposure almost eliminated inorganic sulfur assimilation (Natorff et al., 1993)