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The precursors of IL-18 and IL-1 are cleaved into biologically active mature IL-18 and IL-1 by activated Caspase-1 and secreted through the cell membrane pyrototic pores

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J Transl Med 19:111 Malaguarnera M, Gargante MP, Cristaldi E et al (2008) Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue