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Cancer cells not only switch from OXPHOS to lactate-dependent energy-generating pathways, but also upregulate antioxidant-related genes [e.g., NF-E2-related factor 2 (Nrf2)] to overcome a wide range of oxidative stress [27]

[] Although most of them are metabolized in the liver and intestines, a small amount can persist in the bloodstream and organs such as the kidneys, lungs, heart, and brain

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Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions

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