Pharmacol Biochem Behav 48(4):887892
J., Altmann, P., Rajagopalan, B., Graham, K., Cooper, R., Bonomo, Y., and Styles, P
TMAO increases renal fibrosis: evidence from an intervention in male mice To corroborate our in vitro findings suggesting that TMAO directly increases myofibroblast trans-differentiation and establish in vivo relevance, we performed Unilateral Ureter Obstruction (UUO) surgery in mice, a model assessing renal fibrosis in the absence of other co-morbidities 51 that could be also impacted by TMAO
while the SHAM group was exposed to air during the same period of time as previously described (Al-Odat et al., , 0.1 mg/g, i.p., Abbott Australasia Pty
Preclinical Combination Data (ALCAR + Alpha-Lipoic Acid) Preclinical studies in aged rats have demonstrated that combining ALCAR with alpha-lipoic acid (ALA) synergistically improves cognitive function more effectively than either compound alone
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