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For example, if the group exposed to GLP-1 RAs included more women with obesity or diabetes, and both of those conditions are independently linked to kidney malformations, that could help explain the observed association

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Rotate injection sites each week to avoid irritation

Hence, in patients with a history of HF, we encourage the administration of SGLT2is

Concerning signs that require medical attention include: Spreading redness larger than a few inches Red streaks Severe or worsening pain Fever or chills Hives away from the site Facial or throat swelling Any breathing difficulty When symptoms worsen rather than improve, document the site with a photo and contact your clinician promptly so they can assess for infection or a true allergic response

But don't necessarily rush out to get vitamin E