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Major Findings: The majority of weight loss resulted from reductions in fat mass rather than lean mass

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Exendin-4, a GLP-1R agonist, also suppressed basal expression of several inflammatory mediators and in combination with phosphodiesterase inhibitors, decreased CXCL10 expression by IFN- (a type II-interferon) in human islets and in MIN6 cells (a mouse -cell line)

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Mutagenesis and sequencing primer sequences are listed in Table 1