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The DPP-4 inhibitors sitagliptin, alogliptin and saxagliptin have demonstrated cardiovascular safety in clinical trials involving patients at a high cardiovascular risk.3638 In the SAVOR-TIMI 5 study, saxagliptin was associated with a significant increase in hospital admission due to heart failure,38 a situation not observed with the other molecules

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It lists the indications as type 2 diabetes, prediabetes, obesity and cardiovascular risk reduction, with personal or family history of medullary thyroid cancer and multiple endocrine neoplasia type 2 as contraindications

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