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Etiology Genetics COL5A1 or COL5A2 mutation in 40-50% less common mutations identified below Associated conditions Connective tissue disorder characterized by Classification Berlin Classification (1988) - revised Types I - XI exist Villefranche Classification (1998) Presentation Symptoms double-jointedness easily damaged, bruised, & stretchy skin easy scarring & poor wound healing increased joint mobility, joint popping, early arthritis chronic musculoskeletal pain (50%) Physical exam a score of 5 or more on 9-point Beighton-Horan scale defines joint hypermobility

201 In a preliminary study, 10 people with obstructive sleep apnea were found to have dysfunction of the delicate lining of blood vessels (the endothelium) compared with healthy controls, which improved to a level comparable with that of controls after a single 500-mg dose of intravenous vitamin C

It is unlikely that the inhibitory product in the CSs could be hydrogen peroxide or lactic acid since L

Key Takeaway Should you run TB-500 continuously, or should you cycle on and off