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For a small number of trials, the complete set of data values (change and uncertainty) for each outcome was not reported and was back-calculated using established methods

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Here is the typical timeline, broken down by phase

Inject the medication: Gently insert the needle under the skin at the chosen injection site

The key difference is severity and persistence

*Correspondence: Juhyun Song [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers