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Strategies in translating the therapeutic potentials of host defense peptides

I., Miura, K

Mitochondrial-mediated ROS cause oxidative damage to cellular structures, particularly mitochondrial DNA, somatic mutations, genome instability, inactivation of tumor suppressor genes, alterations in metabolic and signaling pathways with simultaneous activation of compensatory antioxidant mechanisms, all of which contribute to cell transformation and thus promote various types of cancer [42]

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Glutathione is an antioxidant in the body made up of three amino acids: glycine, cysteine and glutamate