Practical Research-Context Considerations For completeness, and strictly as educational context rather than usage guidance, a few practical points recur whenever these blends are discussed in a laboratory framing with the standing caveat that none of this implies human use is appropriate
Although studies using EEC lines and tissue explants have demonstrated GLP-1 release in response to T1R2/T1R3 ligands, the in vivo relevance of sweet TR activation on incretin secretion still remains unclear, since others have been unable to demonstrate functional activity of T1R2/T1R3 in primary cultured L cells or in perfused intestinal preparations (15, 19)
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