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A 2024 pharmaceutical review in Pharmaceuticals raised tumorigenesis as a theoretical risk, though a 2025 response published in the same journal directly countered the concerns
Exerc Sport Sci Rev 30(1):1519 Sandri M, Barberi L, Bijlsma AY, Blaauw B, Dyar KA, Milan G, Mammucari C, Meskers CG, Pallafacchina G, Paoli A, Pion D, Roceri M, Romanello V, Serrano AL, Toniolo L, Larsson L, Maier AB, Munoz-Canoves P, Musaro A, Pende M, Reggiani C, Rizzuto R, Schiaffino S (2013) Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway
As demand surges and pipelines swell, the real prize lies beyond weight loss: in diabetes prevention, cardiovascular outcomes, and even neurodegenerative disease
Nonetheless, use of HU therapy in SCD has expanded substantially in recent years
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