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Nicotine: Most, but not all, e-liquids contain nicotine, the addictive stimulant derived from tobacco
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Furthermore, smoking induces vascular vasoconstriction, sinusoidal endothelial dysfunction, and smooth muscle proliferation, leading to hypoxia, capillarization of sinusoids, and further activation of HSCs [18]
An acute effect of cigarette smoking on platelet function: a possible link between smoking and arterial thrombosis