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This mitochondrial fraction is functionally critical, as demonstrated by the restoration of ferroptosis sensitivity in CHAC1-null cells through expression of a mitochondrially targeted CHAC1 (Ward et al., 2024)

Wei XL, Tao MH, Li RH, Ge SH, Xiao W

[2] [3] Many patients experience significant weight loss during the initial months of treatment, but it is not uncommon to encounter a weight loss plateau a period where weight remains stable despite continued medication use and adherence to lifestyle modifications