Tirzepatide is metabolized through proteolytic cleavage and does not rely on cytochrome P450 enzymes, while sermorelin undergoes rapid enzymatic degradation in plasma
During the first 24 weeks, you may experience: Nausea (the most frequently reported side effect, affecting 20-40% of patients initially, varying by product and dose according to SmPC data) [20] [17] Reduced appetite or early satiety Occasional vomiting Mild abdominal discomfort or bloating Changes in bowel habits, including constipation or diarrhoea These effects typically diminish as your body adjusts to the medication, usually within 48 weeks
And a third patient who continued the medication with conservative management (hydration and saliva substitutes) saw gradual recovery over 16 weeks
Your doctor may adjust doses and teach you how to recognise and treat hypos
Availability Issues: While the FDA has declared that the shortage is over, sporadic supply issues may still occur in certain areas due to high demand
Your healthcare provider may recommend restarting at a lower dose and titrating back up as your appetite and gastrointestinal function normalize
