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For example, dogs who cannot absorb Vitamin B12 in their intestines do not respond to oral vitamin B12 supplementation

High doses of B12 may worsen the disease and cause irreversible damage to the optic nerve

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US National Library of Medicine National Institutes of Health (2010)

I often mix vitamin B12 with Lidocaine or Bupivacaine (or both) for trigger point injections and I find good results

Vitamin B supports the immune system and guards against infections, too