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Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial The Lancet, 2023

It can have protesticular effects as well from the IGF1 perspective

A fixed effect meta-analysis increased the significance of the observed association ( P = 1.1 10 10 , odds ratio = 0.54)

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[8] This mechanism makes BioPerine valuable in thermogenic formulas where maximizing absorption of fat-soluble compounds matters