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This decline adds to many age-related changes including loss of muscle mass and strength, increased body fat (especially visceral fat), decreased bone density, reduced skin thickness and elasticity, impaired healing and healing, and decreased energy and vitality

It also activates VEGFR-2 (promoting angiogenesis), EGR-1 (a transcription factor for tissue repair genes), and the NO-system (nitric oxide signaling)

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""Re: Adrenocortical Hormone Abnormalities in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome""