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In SURPASS-2, which compared tirzepatide to semaglutide 1 mg in 1,879 patients with type 2 diabetes, tirzepatide 5 mg, 10 mg, and 15 mg reduced systolic blood pressure from baseline by 5.6, 7.4, and 8.0 mmHg respectively at 40 weeks, compared to 5.3 mmHg with semaglutide

However, it has not been decided whether it is a causal factor [71, 77]

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Also, while the supplement is marketed as safe for long-term use, the absence of extensive long-term research data raises questions about its prolonged safety and efficacy

However, if the pen was unopened and left out, you should consult your provider, as unopened pens are ideally kept refrigerated until their first use to maintain the manufacturers expiration date