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This is basic physics, not medication failure

References: [1] P B Johansen, J Nowak, C Skjaerbaek, A Flyvbjerg, T T Andreassen, M Wilken, and H Orskov (1999) Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats Growth Hormone and IGF Research Journal, 1999 Apr, Volume 9 (Issue 2), Pages 106-13

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topical application for skin surface indications including anti-aging, wrinkle reduction, and localized wound care