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HSP90 and HSP70 interact with components of the apoptotic machinery and kinases such as Akt, influencing the balance between survival and death signalling, while GRP78 integrates ER stress responses with downstream UPR and apoptotic cascades [19,42]

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The sterile diluent is then added slowly to the vial, ideally against the inside wall of the container rather than directly onto the peptide powder