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some report sleep disturbances, while others do not

We previouly reported that MOTS-c administration increased endogenous levels of myocardial MOTS-c and activated AMPK, improves myocardial mechanical efficiency, enhanced cardiac contractility, and improved diastolic function during exercise training 32

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The expression of the genes encoding AgRP and POMC neuropeptides is regulated by insulin and leptin via Foxo1 and the STAT factor Stat3 (Kitamura et al., 2006)

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doi: 10.1111/acel.12880 203 WaltonRGDunganCMLongDETuggleSCKosmacKPeckBDet al