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doi: 10.1016/s1470-2045(09)70358-4 179

Future longitudinal studies need to examine the development of symptoms across the life course of e-cigarette users, particularly since these devices have only emerged in recent years and diversifying at a rapid pace

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Although the precise etiology of RA is not fully defined, it is well established that the disease develops over several stages spanning many years referred to as the pre-clinical stage of RA