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( b ) The expression of cytosolic or nuclear IDO1 in U2OS cells treated with 100 M H 2 O 2 or combined with pre-treated with 5 mM NAC for 12 h was analyzed by Western blot

In addition, the inhibition of NLRP3 activation by GLP-1RAs requires regulation of the mitochondrial pathway

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Zhai et al., 2013

Notably, LPS-induced NF-B activation occurs in two phases: an early phase (0.5-2 hours after stimulation) driven by TLR4 signaling, and a late phase (8-12 hours after stimulation) sustained by cytokines such like TNF- and IL-1 generated during the early phase (81)