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Of note, miR-320d was not differentially expressed between COPD and control at baseline, but showed lower expression in response to CSE in COPD compared to control-derived cells, where CSE induced a significant upregulation of miR-320d (Supplementary Fig

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Bicarbonate and electrolytes are checked to screen for metabolic acidosis, an adverse effect of topiramate treatment that is readily reversible (weekly as required)

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