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E.BberS.TapiE.et al (2014)

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The phase 2 and phase 3 trials focused primarily on total body weight reduction

In EGFR-mutant nonsmall cell lung cancer, the gatekeeper mutation EGFR T790M is detectable in treatment-nave tumors at allele frequencies as low as 0.011% using extremely sensitive assays and rapidly expands under first-generation EGFR tyrosine kinase inhibitors to drive disease progression