BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase
KEY TAKEAWAYS PCOS is now officially called PMOS - Polyendocrine Metabolic Ovarian Syndrome - shifting focus from ovarian problems to metabolic dysfunction 70 million women globally are affected during reproductive years, with 70% remaining undiagnosed The condition can occur at any weight and is driven by insulin resistance and other metabolic signals, not ovarian problems Treatment should focus on metabolic health rather than weight loss or ovarian interventions The name change parallels similar shifts in medicine like MASLD replacing non-alcoholic fatty liver disease NOTABLE QUOTE "Most patients with this label that they've had in the past, the PCOS label, feel a sense of hopelessness, and even join support groups and things like that, and thinking that this will be a condition they have forever
This allows patients to compare a full range of treatment options in one program
Obesity-mediated immune modulation: one step forward, (Th)2 steps back
If muscle mass goes with it, youre left with less support around the spine
With Sofwave, youre building new collagen and elastin and that process starts to peak around 4-6 weeks and continues to develop for about 3-6 months, whether youre talking about a laser, radiofrequency, or ultrasound like Sofwave
