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Eric Topol, MD - Your focus on evidence over opinion is essential, particularly as public discourse drifts away from data

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Wash Your Hands Prevent infection by thoroughly washing your hands or using hand sanitizer before handling your medication

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Metabolic adaptation causes rapid rebound hunger and weight regain, often exceeding initial weight loss within months

Important considerations when combining HRT and GLP-1 Before starting or combining HRT and GLP-1, there are several factors to discuss with a clinician: Not all HRT formulations are the same: Transdermal estrogen and micronized progesterone are often preferred when combining with other medications Individual risk factors matter: History of certain cancers, cardiovascular issues, or blood clots affects HRT suitability Monitoring is important: Regular check-ins help ensure both treatments are working well together Timing and dosing: A clinician can help determine whether to start treatments simultaneously or sequentially A personalized approach to weight loss during hormonal changes Because every body responds differently to hormonal shifts and medications, personalized care makes a meaningful difference in outcomes