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(PubMed) Hendler S, Rorvik D, eds

CONCLUSION In conclusion, vitamin B12 deficiency management involves various administration routes, including intramuscular (IM), oral, and subcutaneous methods

Literature suggests the immunological dysfunction seen in Long COVID may be driven by mast cell hyperactivation

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

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