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North America leads at 34.6% in 2025, anchored by the United States mature regulatory framework with 41 FDA-authorized e-cigarettes, strong DTC e-commerce channels, and sustained consumer adoption of PMTA-compliant brands

Inflating the bowel with air sometimes causes temporary problems such as pain or bloating

All participants underwent a Level-1 (L1) assessment, including physical and cognitive examinations, a structured interview, touchscreen questionnaires, and biomaterial collection

Stomach contents thus exit more slowly into the duodenum of the digestive tract, a medical sign called delayed gastric emptying

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