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measured MMP1, MMP2, TIMP1, and TIMP2 gene expression in human adult dermal fibroblasts exposed to GHK-Cu at 0.01, 1, and 100 nanomolar concentrations and found dose-dependent increases in both MMPs and their inhibitors 11

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This condition results from disruption in glucose metabolism, often stemming from insufficient insulin production by the pancreas, reduced in insulin effectiveness in body tissues (insulin resistance), or a combination of these factors, which is particularly common among older adults [556]