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The dosing conditions, schedule and washout period in both studies ensured there was no effect of food or drugdrug interaction between the two drugs evaluated in each study
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Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factorbinding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]
This last point is critical because food and beverages can interfere with the mucosal absorption of semaglutide, significantly reducing bioavailability