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Cummings: Lithium alters a whole host of things, including a lot of metabolic parameters in terms of basic energy input and output
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Noticeably, DHA also upregulated a Gpx4 CIRT (Cytoplasmic Intron-sequence Retaining Transcripts), a novel Gpx4 splicing variant, harboring part of the first intronic region, which according to the sentinel RNA hypothesis would expand the ability of Gpx4 (and DHA) to provide neuronal antioxidant defense independently of conventional nuclear splicing in cellular compartments, like dendritic zones, located away from nuclear compartment
Control group was carried out without CCl4 exposure