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The participants were given different doses of bupropion in combination with a calorie-restricted diet and regular exercise for 24 weeks

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The American College of Physicians (ACP) similarly emphasizes appropriate duration of therapy to balance symptom control with potential risks

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway

PMID 16168066