He also added, Its almost a pointless exercise talking to FDA because they never give you clarity. When I asked the FDA the same question about synthetic nicotines status as a tobacco product, the agency replied, These products will be evaluated on a case-by-case basis. Given that the FDA has asserted it can regulate even vaping liquids that contain no nicotine though, it does not seem poised to turn a blind eye to synthetic nicotine on technical grounds
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The German Federal Institute for Risk Assessment confirmed in its previous study substantially reduced toxicant levels for selected HTPs and provided an initial assessment in 2017 (49)
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Some users report effects lasting 24 to 48 hours depending on dose, individual metabolism, and body composition
Available from: /pmc/articles/PMC4800444/