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Barrier breakdown allows more allergens in, which triggers more Th2 activation, which further weakens the barrier

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They remain compositionally and conformationally stable only within a relatively narrow range of pH and osmolarity, and many require additionally supportive formulation components to remain in solution, particularly over time (2)

Weng, Q

The iron load of lipocalin-2 (LCN-2) defines its pro-tumour function in clear-cell renal cell carcinoma