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2014 PMI launches Japans first Heated Product, IQOS in Nagoya 2016 BAT launches its first Heated Product, glo, in Sendai, and Japan Tobacco Inc

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13 There is evidence that these types of primary care relevant interventions can prevent smoking initiation with children and adolescents

These advancements have demonstrated that the respiratory tract is not devoid of microorganisms, but rather supports a complex and diverse microbiome across both the upper and lower airways [36,37,38]

Twenty years since the adoption of the WHO Framework Convention on Tobacco Control, we have many successes to celebrate, but the tobacco industry continues to evolve and so must we, said Dr Tedros Adhanom Ghebreyesus, WHO Director-General